Genome-Wide Gene Expression Profiling of Patients With ITP Receiving Thrombopoietin Mimetics

Trial ID or NCT#

NCT01727999

Status

not recruiting iconNOT RECRUITING

Purpose

Introduction: Ineffective platelet production has been proven to play a role in the etiology of Immune Thrombocytopenia (ITP) in addition to increased platelet destruction. The second-generation thrombopoietin (TPO) mimetics have shown good efficacy in boosting platelet counts in the great majority of patients with chronic ITP in several clinical trials.1, 2 Nevertheless, about 20% of patients with ITP fail to respond to the TPO mimetic treatment. Those treatment-resistant patients are un-characterized and the reasons for the lack of response have not been studied. The identification of predictive blood biomarkers of patients' response to treatment will be useful in reducing both cost and potential side effects; and it will be of equal importance and interest to investigate the molecular mechanisms underlying the patients' heterogeneous responses to TPO mimetic treatment. Specific Aims: 1. To identify blood classifier genes which correlate with patients' response to TPO mimetic treatment. 2. To compare the blood gene expression changes in responders and non-responders after TPO mimetic treatment and explore the possible molecular mechanisms accounting for the non-responsiveness to the treatment.

Official Title

Genome-Wide Gene Expression Profiling of Patients With ITP Receiving Thrombopoietin Mimetics

Eligibility Criteria

Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. * clinical diagnosis of ITP TPO treatment
Exclusion Criteria:
  1. * thrombocytopenia not due to ITP

Investigator(s)

James L. Zehnder, M.D.
James L. Zehnder, M.D.
Hematologist, Pathologist
Professor of Pathology (Research) and of Medicine (Hematology)

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Contact

James L Zehnder, MD
650-723-9232