Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study

Trial ID or NCT#

NCT03680781

Status

not recruiting iconNOT RECRUITING

Purpose

This study evaluates the effectiveness of re-treatment using accelerated schedule of intermittent theta-burst stimulation for treatment-resistant depression. This is an open label study.

Official Title

Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study

Eligibility Criteria

Ages Eligible for Study: 18 Years to 75 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. * Male or female, 18 to 75 years of age.* Able to provide informed consent.* Diagnosed with Major Depressive Disorder (MDD) or bipolar affective disorder 2 and currently experiencing a Major Depressive Episode (MDE).* prior exposure to rTMS* Participants must qualify as "moderate or severe treatment refractory" using the Maudsley staging method.* Participants may continue antidepressant regimen, but must be stable for 6 weeks prior to enrollment in the study. They must maintain that same antidepressant regimen throughout the study duration.* Participants are required to have a stable psychiatrist for the duration of study enrollment.
Exclusion Criteria:
  1. * History of MI, CABG, CHF, or other cardiac history* Any neurological conditions* History of epilepsy* OCD* Independent sleep disorder* Autism Spectrum Disorder
View All Criteria
Show Less

Investigator(s)

Nolan Williams
Nolan Williams
Deep brain stimulation specialist, Neuroimaging specialist, Psychiatrist
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories & Clinical Translational Neurosciences Incubator) and, by courtesy, of Radiology (Neuroimaging and Neurointervention)

Contact us to find out if this trial is right for you.

Contact

Claudia Tischler, BA
650-498-8535

View on ClinicalTrials.gov