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Targeted Bias: The Next Swing at IL2 Therapy.
Targeted Bias: The Next Swing at IL2 Therapy. Cancer discovery Kulhanek, K. R., Kalbasi, A. 2024; 14 (7): 1145-1146Abstract
Despite its long history of toxicity and limited efficacy, IL2 has re-entered the clinic as a companion to the recently FDA-approved tumor infiltrating lymphocyte therapy. In back-to-back articles, Moynihan and Kaptein introduce a new fusion protein that delivers a biased IL2 mutein to CD8 T cells. See related article by Moynihan et al., p. 1206 (6). See related article by Kaptein et al., p. 1226 (7).
View details for DOI 10.1158/2159-8290.CD-24-0558
View details for PubMedID 38946323