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PolyQ Disease: Too Many Qs, Too Much Function?
PolyQ Disease: Too Many Qs, Too Much Function? NEURON Kratter, I. H., Finkbeiner, S. 2010; 67 (6): 897–99Abstract
The nature of the gain-of-function toxicity found in polyglutamine (polyQ) diseases has been the subject of considerable debate. In this issue of Neuron, Duvick et al. and Nedelsky et al. show that, in two of these diseases, pathology is mediated by normal protein activity.
View details for DOI 10.1016/j.neuron.2010.09.012
View details for Web of Science ID 000282801100001
View details for PubMedID 20869586
View details for PubMedCentralID PMC3989162