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Optic Chiasm Morphometric Changes in Multiple Sclerosis: Feasibility of a Simplified Brain MRI Measure of White Matter Atrophy.
Optic Chiasm Morphometric Changes in Multiple Sclerosis: Feasibility of a Simplified Brain MRI Measure of White Matter Atrophy. Clinical anatomy (New York, N.Y.) Zaccagna, F., Matys, T., Massoud, T. F. 2019Abstract
Sophisticated volume measurements of brain structures on MRI may improve specificity in determining long-term progression of multiple sclerosis (MS), but these techniques are laborious. The optic chiasm (OC) is a white matter (WM) structure clearly visible on routine MRI and is related to the optic nerves (ONs), which are known to atrophy in MS. We hypothesized that OC morphometric measurements would show OC atrophy in MS compared to normal patients. If so, this could help establish a novel simplified brain MRI measure of WM atrophy in MS patients. We retrospectively evaluated standard brain MRIs of 97 patients with known MS, and 98 normal individuals. We electronically measured eight OC morphometrics on axial T2WIs and midsagittal T1WIs: OC width and antero-posterior (AP) diameter, diameters of each ON and optic tract (OT), and angles between the ONs or OTs. Mean OC width, AP diameter and height in MS patients were 11.83±1.25mm (95%CI 11.58-12.09), 2.99±0.65mm (95%CI 2.85-3.12), and 2.09±0.37mm (95%CI 2-2.19), respectively. In normal individuals they were 12.1±1.4mm (95%CI 11.78-12.34), 3.43±0.63mm (95%CI 3.3-3.58), and 2.15±0.37mm (95%CI 2.07-2.23), respectively. There were statistically significant differences between MS patients and controls for AP diameter (p=0.000), but not for width (p=0.204) or height (p=0.183). The ONs were significantly smaller in MS (p<0.0017), but not the OTs. Thus, the OC is significantly atrophied in an unstratified cohort of MS patients. Future studies may establish an MRI OC morphometric index to evaluate demyelinating disease in the brain. This article is protected by copyright. All rights reserved.
View details for DOI 10.1002/ca.23446
View details for PubMedID 31381196