Biography
At Stanford, Dr. van Roessel sees adult mood and anxiety disorders outpatients through the Assessment Clinics and participates in resident training and patient care as director of the resident Continuity Clinic and as a supervisor in psychodynamic psychotherapy. He additionally directs the third-year resident curriculum in psychopathology and psychopharmacology. As a member of the department's Rodriguez Translational Therapeutics Lab, he sees individuals with obsessive-compulsive spectrum disorders for evaluations and research-protocol driven clinical treatment and contributes to and leads clinical neuroscience studies pioneering rapid-acting interventions in OCD. Clinically motivated research interests include the nature and neural correlates of metacognitive ‘awareness’ (insight) in OCD and related disorders, and particularly the relationship of awareness to mechanisms of attentional control.
Dr. van Roessel pursued research training in basic neuroscience prior to his clinical training, completing an MPhil in Biology via the Open University, UK, for research performed at the Max Planck Institute for Developmental Biology in Tübingen Germany, and a PhD in molecular and developmental neurobiology at the University of Cambridge, UK. He has contributed to work in the lab of Dr Julia Kaltschmidt (Stanford) on studies of GABAergic/Glutamatergic interneuronal circuity in mouse. He received a 2018 NARSAD Young Investigator Award to pursue study of nitrous oxide as a rapid-acting treatment for OCD, he was a 2020-2022 Miller Foundation Fellow, and from 2020 to 2022 was a Advanced Fellow in Mental Illness Treatment and Research via the Sierra Pacific Mental Illness Research, Education, and Clinical Center of the Palo Alto VA. Dr. van Roessel is a Fellow of the American Psychiatric Association and a member of the American College of Psychiatrists.
Professional Summary
Education & Certifications
- PhD Training: University of Cambridge (2003) United Kingdom
- Board Certification: American Board of Psychiatry and Neurology, Psychiatry (2011)
- Residency: New York Presbyterian Hospital - Columbia University (2011) NY
- Medical Education: Stanford University School of Medicine (2007) CA
Publications
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Care within a Veterans Hospital - Earlier detection of colon cancer
van Roessel, P., Rouse, R. V., & Wren, S. M. (2007). Care within a Veterans Hospital - Earlier detection of colon cancer. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 21(8), 1434–40. -
Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord
Mende, M., Fletcher, E. V., Belluardo, J. L., Pierce, J. P., Bommareddy, P. K., Weinrich, J. A., … Kaltschmidt, J. A. (2016). Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord. NEURON, 90(6), 1189–1202. -
A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry.
Zhang, J., Weinrich, J. A., Russ, J. B., Comer, J. D., Bommareddy, P. K., DiCasoli, R. J., … Kaltschmidt, J. A. (2017). A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. Cell Reports, 21(3), 666–78. -
Independent regulation of synaptic size and activity by the anaphase-promoting complex.
van Roessel, P., Elliott, D. A., Robinson, I. M., Prokop, A., & Brand, A. H. (2004). Independent regulation of synaptic size and activity by the anaphase-promoting complex. Cell, 119(5), 707–18. -
Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins.
van Roessel, P., & Brand, A. H. (2002). Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins. Nature Cell Biology, 4(1), E15–20. -
Spreading silence with Sid.
van Roessel, P., & Brand, A. H. (2004). Spreading silence with Sid. Genome Biology, 5(2), 208. -
Region-specific apoptosis limits neural stem cell proliferation.
Brand, A. H., & van Roessel, P. J. (2003). Region-specific apoptosis limits neural stem cell proliferation. Neuron, 37(2), 185–87. -
Activity of long-wavelength cones under scotopic conditions in the cyprinid fish Danio aequipinnatus.
van Roessel, P., Palacios, A. G., & Goldsmith, T. H. (1997). Activity of long-wavelength cones under scotopic conditions in the cyprinid fish Danio aequipinnatus. Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology, 181(5), 493–500. -
Exploring Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Extinction Learning-Based Treatment Outcome in Obsessive-Compulsive Disorder: A Pilot Study.
Linkovski, O., Wheaton, M. G., Zwerling, J., Odgerel, Z., van Roessel, P., Filippou-Frye, M., … Rodriguez, C. I. (2018). Exploring Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Extinction Learning-Based Treatment Outcome in Obsessive-Compulsive Disorder: A Pilot Study. Journal of Clinical Psychopharmacology. -
Two-color GFP imaging demonstrates cell-autonomy of GAL4-driven RNA interference in Drosophila.
van Roessel, P. J., Hayward, N. M., Barros, C. S. C., & Brand, A. H. (2002). Two-color GFP imaging demonstrates cell-autonomy of GAL4-driven RNA interference in Drosophila. Genesis, 34(1-2). -
Exploring Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Extinction Learning-Based Treatment Outcome in Obsessive-Compulsive Disorder A Pilot Study
Linkovski, O., Wheaton, M. G., Zwerling, J., Odgerel, Z., van Roessel, P., Filippou-Frye, M., … Rodriguez, C. I. (2019). Exploring Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Extinction Learning-Based Treatment Outcome in Obsessive-Compulsive Disorder A Pilot Study. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 39(1), 91–93. -
Clutter Blindness as an Insight Proxy in Hoarding Disorder: A Hypothesis-Generating Study
van Roessel, P., Sanchez, C., Linkovski, O., Sandhu, T., Wright, B., McCarthy, E., … Rodriguez, C. (2018). Clutter Blindness as an Insight Proxy in Hoarding Disorder: A Hypothesis-Generating Study. NEUROPSYCHOPHARMACOLOGY. NATURE PUBLISHING GROUP. -
Exploring BDNF Val66Met Polymorphism and Extinction Learning-Based Treatment Outcome in OCD: A Pilot Study
Linkovski, O., Wheaton, M., Zwerling, J., Oderel, Z., van Roessel, P., Filippou, M., … Rodriguez, C. (2018). Exploring BDNF Val66Met Polymorphism and Extinction Learning-Based Treatment Outcome in OCD: A Pilot Study. NEUROPSYCHOPHARMACOLOGY. NATURE PUBLISHING GROUP. -
Neurocognitive Correlates of Insight in Hoarding Disorder
van Roessel, P., Varias, A., Sanchez, C., Sandhu, T., Shen, H., Jo, B., & Rodriguez, C. (2019). Neurocognitive Correlates of Insight in Hoarding Disorder. NEUROPSYCHOPHARMACOLOGY, 44(SUPPL 1), 159. -
Self-Reported Depressive Symptoms in Active and Retired Professional Hockey Players
Aston, P., Filippou-Frye, M., Blasey, C., van Roessel, P. J., & Rodriguez, C. (2020). Self-Reported Depressive Symptoms in Active and Retired Professional Hockey Players. CANADIAN JOURNAL OF BEHAVIOURAL SCIENCE-REVUE CANADIENNE DES SCIENCES DU COMPORTEMENT, 52(2), 97–106. -
Does Nitrous Oxide Help Veterans With Posttraumatic Stress Disorder? A Case Series.
Varias, A., van Roessel, P., Parsiani, M., Filippou-Frye, M., Neylan, T. C., Nagele, P., … Rodriguez, C. I. (2020). Does Nitrous Oxide Help Veterans With Posttraumatic Stress Disorder? A Case Series. The Journal of Clinical Psychiatry, 81(4). -
Examining subjective sleep quality in adults with hoarding disorder.
Mahnke, A. R., Linkovski, O., Timpano, K., van Roessel, P., Sanchez, C., Varias, A. D., … Rodriguez, C. I. (2020). Examining subjective sleep quality in adults with hoarding disorder. Journal of Psychiatric Research. -
Accelerated Neuromodulation Therapy for Obsessive-Compulsive Disorder.
Williams, N. R., Sudheimer, K. D., Cole, E. J., Varias, A. D., Goldstein-Piekarski, A. N., Stetz, P., … Rodriguez, C. I. (2021). Accelerated Neuromodulation Therapy for Obsessive-Compulsive Disorder. Brain Stimulation. -
Deconstructing Ketamine-Induced Changes in Cortisol and Dissociative and Affective States in a Controlled Mechanistic Study
Hack, L. M., Zhang, X., Brawer, J., Gray, N., Heifets, B., Suppes, T., … Williams, L. (2022). Deconstructing Ketamine-Induced Changes in Cortisol and Dissociative and Affective States in a Controlled Mechanistic Study. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC. -
Acute Ketamine Modulates Cognitive Control Network Activity During Cognitive Inhibition: Evidence From a Mechanistic Trial
Zhang, X., Hack, L., Brawer, J., Gray, N., Heifets, B., Suppes, T., … Williams, L. (2022). Acute Ketamine Modulates Cognitive Control Network Activity During Cognitive Inhibition: Evidence From a Mechanistic Trial. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC. -
Valence processing alterations in SAPAP3 knockout mice and human OCD.
Kajs, B. L., van Roessel, P. J., Davis, G. L., Williams, L. M., Rodriguez, C. I., & Gunaydin, L. A. (2022). Valence processing alterations in SAPAP3 knockout mice and human OCD. Journal of Psychiatric Research, 151, 657–666. -
Treatment-resistant OCD: Pharmacotherapies in adults.
van Roessel, P. J., Grassi, G., Aboujaoude, E. N., Menchon, J. M., Van Ameringen, M., & Rodriguez, C. I. (2022). Treatment-resistant OCD: Pharmacotherapies in adults. Comprehensive Psychiatry, 120, 152352. -
Anosognosia in hoarding disorder is predicted by alterations in cognitive and inhibitory control.
van Roessel, P. J., Marzke, C., Varias, A. D., Mukunda, P., Asgari, S., Sanchez, C., … Rodriguez, C. I. (2022). Anosognosia in hoarding disorder is predicted by alterations in cognitive and inhibitory control. Scientific Reports, 12(1), 21752. -
Identity gripping or identity flight? Two distinct experiences correlated with self-reported depression in retired professional ice hockey players
Aston, P. R. R., Brewer, M. A. A., Kieschnick, D. W. W., Allen, M. C. C., van Roessel, P. J. J., Lavallee, D. E. E., & Rodriguez, C. I. I. (2022). Identity gripping or identity flight? Two distinct experiences correlated with self-reported depression in retired professional ice hockey players. INTERNATIONAL JOURNAL OF SPORT AND EXERCISE PSYCHOLOGY. -
Cognitive Control Predicts Alleviation of OCD Symptoms by Ketamine
van Roessel, P., Asgari, S., Jo, B., Williams, L., & Rodriguez, C. (2022). Cognitive Control Predicts Alleviation of OCD Symptoms by Ketamine. NEUROPSYCHOPHARMACOLOGY. SPRINGERNATURE. -
Efficacy of Ketamine in Unmedicated Adults With Obsessive-Compulsive Disorder: A Randomized Controlled Trial
Rodriguez, C., Chen, C.-M., Glover, G., Jo, B., Spielman, D., Williams, L., … Wright, B. (2022). Efficacy of Ketamine in Unmedicated Adults With Obsessive-Compulsive Disorder: A Randomized Controlled Trial. NEUROPSYCHOPHARMACOLOGY. SPRINGERNATURE. -
Cognitive Control Predicts Alleviation of OCD Symptoms by Ketamine
van Roessel, P., Asgari, S., Jo, B., Williams, L., & Rodriguez, C. (2022). Cognitive Control Predicts Alleviation of OCD Symptoms by Ketamine. NEUROPSYCHOPHARMACOLOGY. SPRINGERNATURE. -
Efficacy of Ketamine in Unmedicated Adults With Obsessive-Compulsive Disorder: A Randomized Controlled Trial
Rodriguez, C., Chen, C.-M., Glover, G., Jo, B., Spielman, D., Williams, L., … Wright, B. (2022). Efficacy of Ketamine in Unmedicated Adults With Obsessive-Compulsive Disorder: A Randomized Controlled Trial. NEUROPSYCHOPHARMACOLOGY. SPRINGERNATURE. -
Early life stress in adults with hoarding disorder: A mixed methods study
Sanchez, C., Linkovski, O., van Roessel, P., Steinberg, N. M., McCarthy, E., Rodriguez, P. A. M., … Rodriguez, C. I. (2023). Early life stress in adults with hoarding disorder: A mixed methods study. JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS, 37. -
Hoarding disorder: Questions and controversies
van Roessel, P., Rodriguez, P. A. M., Frost, R. O., & Rodriguez, C. I. (2023). Hoarding disorder: Questions and controversies. JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS, 37. -
Augmenting group hoarding disorder treatment with virtual reality discarding: A pilot study in older adults
Raila, H. (2023). Augmenting group hoarding disorder treatment with virtual reality discarding: A pilot study in older adults. Augmenting Group Hoarding Disorder Treatment with Virtual Reality Discarding: A Pilot Study in Older Adults. -
Cognitive Control Predicts Alleviation of OCD Symptoms by Ketamine
Van Roessel, P., Asgari, S., Jo, B., Williams, L., & Rodriguez, C. (2023). Cognitive Control Predicts Alleviation of OCD Symptoms by Ketamine. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC. -
Acute Effects of MDMA on Intrinsic Functional Connectomes Associated With Altered States of Consciousness and Defensiveness
Zhang, X., Hack, L., Heifets, B., Suppes, T., van Roessel, P., Yesavage, J., … Williams, L. (2023). Acute Effects of MDMA on Intrinsic Functional Connectomes Associated With Altered States of Consciousness and Defensiveness. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC. -
Efficacy of Ketamine in Unmedicated Adults With OCD: A Randomized Controlled Trial
Rodriguez, C., Chen, C.-M., Glover, G., Jo, B., Spielman, D., Williams, L., … Wright, B. (2023). Efficacy of Ketamine in Unmedicated Adults With OCD: A Randomized Controlled Trial. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC. -
Acute Effects of MDMA on Negative Affective Brain Circuit Function: A Randomized Controlled Mechanistic Trial
Hack, L., Zhang, X., Heifets, B., Suppes, T., van Roessel, P., Yesavage, J., … Williams, L. (2023). Acute Effects of MDMA on Negative Affective Brain Circuit Function: A Randomized Controlled Mechanistic Trial. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC. -
Ketamine's Acute Effects on Negative Brain States are Mediated Through Distinct Altered States in Humans
Zhang, X., Hack, L., Heifets, B., Suppes, T., Van Roessel, P., Yesavage, J., … Williams, L. (2023). Ketamine's Acute Effects on Negative Brain States are Mediated Through Distinct Altered States in Humans. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC. -
Augmenting group hoarding disorder treatment with virtual reality discarding: A pilot study in older adults.
Raila, H., Avanesyan, T., Valentine, K. E., Koo, B., Huang, C., Tsutsumi, Y., … Rodríguez, C. I. (2023). Augmenting group hoarding disorder treatment with virtual reality discarding: A pilot study in older adults. Journal of Psychiatric Research, 166, 25–31. -
Ketamine's acute effects on negative brain states are mediated through distinct altered states of consciousness in humans.
Hack, L. M., Zhang, X., Heifets, B. D., Suppes, T., van Roessel, P. J., Yesavage, J. A., … Williams, L. M. (2023). Ketamine's acute effects on negative brain states are mediated through distinct altered states of consciousness in humans. Nature Communications, 14(1), 6631. -
Randomized waitlist-controlled trial of buried in treasures facilitated support groups and in-home uncluttering (BIT+) for hoarding disorder.
Wheaton, M. G., Varias, A. D., Sandhu, T., Munoz Rodriguez, P. A., Mukunda, P., Filippou-Frye, M., … Rodriguez, C. I. (2024). Randomized waitlist-controlled trial of buried in treasures facilitated support groups and in-home uncluttering (BIT+) for hoarding disorder. Journal of Psychiatric Research, 176, 58–67.
Clinical Trials
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SHC- Psychiatry Palo Alto, CA
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Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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